get clonazepam online Australia Clonazepam, sold under the brand name Klonopin among others, is a benzodiazepine medication used to prevent and treat anxiety disorders, seizures, bipolar mania, agitation associated with psychosis, obsessive–compulsive disorder (OCD), and akathisia.[10] It is a long-acting[11] benzodiazepine.[10] It possesses anxiolytic, anticonvulsant, sedative, hypnotic, and skeletal muscle relaxant properties. It is typically taken orally (swallowed by mouth) but is also used intravenously.[10][12] Effects begin within one hour and last between eight and twelve hours in adults.[8][1]
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Common side effects may include sleepiness, weakness, poor coordination, difficulty concentrating, and agitation. Clonazepam may also decrease memory formation.[10] Long-term use may result in tolerance, dependence, and life-threatening withdrawal symptoms if stopped abruptly.[10][13] Dependence occurs in one-third of people who take benzodiazepines for longer than four weeks.[9] The risk of suicide increases, particularly in people who are already depressed.[10][14] Use during pregnancy may result in harm to the fetus.[10] Clonazepam binds to GABAA receptors, thus increasing the effect of the chief inhibitory neurotransmitter γ-aminobutyric acid (GABA).[9]
Clonazepam was patented in 1960, marketed in 1964, and went on sale in 1975 in the United States from Roche.[15][16] It is available as a generic medication.[10] In 2023, it was the 62nd most commonly prescribed medication in the United States, with more than 10 million prescriptions.[17][18] In many areas of the world, it is commonly used as a recreational drug.[19][20]
Medical uses
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Clonazepam is prescribed for short-term management of epilepsy, anxiety, obsessive–compulsive disorder (OCD), and panic disorder with or without agoraphobia.[21][22][23]
Seizures
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Clonazepam, like other benzodiazepines, while being a first-line treatment for acute seizures, is not suitable for the long-term treatment of seizures due to the development of tolerance to the anticonvulsant effects.
Clonazepam has been found effective in treating epilepsy in children, and the inhibition of seizure activity seemed to be achieved at low plasma levels of clonazepam.[24] As a result, clonazepam is sometimes used for certain rare childhood epilepsies, but it is ineffective in the control of infantile spasms.[25] Clonazepam is mainly prescribed for the acute management of epilepsy. Clonazepam is effective in the acute control of non-convulsive status epilepticus; the benefits, though, tended to be transient in many people, and the addition of phenytoin for lasting control was required in these patients.[26]
It is also approved for the treatment of typical and atypical absences (seizures) and infantile myoclonic and akinetic seizures.[27] A subgroup of people with treatment-resistant epilepsy may benefit from long-term use of clonazepam; the benzodiazepine clorazepate may be an alternative due to its slow onset of tolerance.